The Overview describes the regulatory process and key points of the evaluation, while the Science Evaluation provides detailed technical information on the assessment of clethodim. [...] The chronic dietary exposure estimate for the general population represents 8.7% of the acceptable daily intake (ADI) and ranges from 6.9% of the ADI (for adults 50-99) to 24.3% of the ADI (for children 1-2 years old). [...] The herbicidal activity of clethodim is due to the inhibition of the initial enzyme in the synthesis of fatty acid, acetyl CoA carboxylase (ACCase), used in building new membranes required for cell growth. [...] The scientific quality of the data is acceptable and the database is considered adequate to define the majority of the toxic effects that may result from exposure to clethodim. [...] The acute aggregate exposure estimate for clethodim at the 95th percentile for the general population is 3.6 % of the ARfD, and therefore is not of concern.