A logical modelling framework for influenza infection / : cadre de modélisation raisonné pour infections grippales

In order to improve consistency tematically test different hypotheses related to and comparability, we propose a relatively simple attributes of the agents, and investigate how popu- logical framework that pertains to the natural history lation phenomena are emerging from individual level of influenza infection with the inclusion of preven- behaviour among a heterogeneous set of interacting tion a [...] The aim of this log- to investigate infection process and outcomes at ical framework is to enhance the utility and uptake the individual level, and simulate disease spread and of modelling for public health responses by building control at the population level.2,3 a conceptual framework for common assumptions, plausible interventions, disease outcomes, and the The proposed framework will consider [...] Each of these interventions could have varying degrees of effect at the individual level, which depend on the immune status of the individuals and other health conditions, as well as the timing of intervention and the level of compliance. [...] While primary prevention of infection is certainly a self-protection mechanism, the effects also extend well beyond the individual by reducing the potential for transmission to contacts and minimizing the spread of infection in the population as a whole. [...] This module the individuals and to the estimated effectiveness of represents the baseline (i.e., in the absence of any interventions, and investigate how macro phenom- intervention) against which the course of infection in ena (e.g., disease spread and evolution) are emerg- other modules is compared.