Assessment The outcomes were explicit The assessment of outcomes was not made blind to There was some recognition that exposure status knowledge of exposure status could It was not possible to ascertain whether the method of have influenced the assessment of assessment of exposure was reliable outcomes. [...] Strengths and Limitations of the Included Cohort Studies using the Sign 50 Methodology Checklist11 Strengths Limitations The outcomes were clearly defined The assessment of outcomes was not made blind to There was some recognition that exposure status knowledge of exposure status could It was not possible to ascertain whether the method of have influenced the assessment of assessment of ex [...] Assessment The outcomes were explicit The assessment of outcomes was not made blind to exposure status There was no recognition that knowledge of exposure status could have influenced the assessment of outcomes It was not possible to ascertain whether the method of assessment of exposure was reliable Evidence from other sources was not used to demonstrate that the method of outcome asses [...] Strengths and Limitations of the Included Cohort Studies using the Sign 50 Methodology Checklist11 Strengths Limitations clinical considerations, the evaluation of the methodology used, and the statistical power of the study, there is no clear evidence of an association between exposure and outcome. [...] Strengths and Limitations of the Included Cohort Studies using the Sign 50 Methodology Checklist11 Strengths Limitations Assessment The outcomes were explicit The assessment of outcomes was not made blind to exposure status There was no recognition that knowledge of exposure status could have influenced the assessment of outcomes It was not possible to ascertain whether the method of asses