cover image: A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder /

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A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder /

17 Mar 2016

Three one-way deterministic sensitivity analyses (DSA) were conducted to examine the effects of changing the inputs for overhead cost, the total volume of CGES tests in the institution, and the number of primary variants found by CGES tests, while other inputs remained the same. [...] The substitution of CMA+WES with WGS resulted in the ratio of incremental cost to incremental diagnostic yield of $51850 in the case of HiSeq X platform and $194906 in the case of HiSeq 2500 platform. [...] The calculation time and the number of nodes required for each step in the bioinformatics pipeline were also obtained from the TCAG bioinformatics manager. [...] The price ranges for large equipment and for some of the small equipment were based on the expert opinion of the TCAG lab manager. [...] The resource use (CPU per hour) for each step was calculated by multiplying the number of computing jobs by the number of CPUs (cores) and time (in minutes) required to complete the job.
autism spectrum disorders human chromosome abnormalities

Authors

Tsiplova, Kate, Zur, Richard M, Ungar, Wendy

Pages
71
Published in
Ottawa, Ontario