cover image: A health technology assessment of transient elastography in liver disease

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A health technology assessment of transient elastography in liver disease

2012

The intent of this report is to use current literature to determine the safety, effectiveness, social considerations and cost- effectiveness of TE for the diagnosis, staging and monitoring of liver damage associated with HBV, HCV, NAFLD, CLD and complications due to liver transplant (LTP). [...] It is estimated that 0.2-2.0% of the population are carriers of HBV or HCV and that 1.0- 5.0% of the HBV carriers, and 75.0- 85.0% of the HCV carriers, will develop chronic hepatitis.16 NAFLD refers to a wide spectrum of liver diseases ranging from simple fatty liver (steatosis), to nonalcoholic steatohepatitis (NASH), to cirrhosis.17 NAFLD is an overall accumulation of fat in the liver cells. [...] PBC is an autoimmune disease which results in the destruction of the bile ducts in the liver.21 Damage to the ducts causes bile to build up in the liver which damages the tissue over time. [...] Women between the ages of 40 and 60 make up 90.0% of PBC cases.21 In some areas of the US and UK the prevalence of PBC is estimated to be as high as 1/4000.16 PSC is a chronic liver disease that is caused by gradual inflammation and scarring of the liver’s bile ducts.21 The flow of bile to the digestive system is impeded by this inflammation. [...] The grade gives an indication of the activity or amount of inflammation and the stage represents the amount of fibrosis or scarring.
health obesity cancer hepatitis medicine medical specialisation paediatrics liver communicable disease liver diseases clinical medicine systematic review liver fibrosis health treatment health sciences medical specialties virus disease diseases and conditions ultrasound cirrhosis liver biopsy elastography acoustic radiation force impulse imaging medical ultrasound diagnostic ultrasonic imaging fibroscan elasticity imaging techniques liver disease nafld
Pages
180
Published in
Canada

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