Purpose of this study: The purpose of this study was to assess the impact of prolonged wakefulness on clinical performance of residents using a high fidelity patient simulator. [...] Purpose of this study: The purpose of this preliminary study was to assess the impact of prolonged wakefulness on clinical performance of residents using a high fidelity patient simulator. [...] Of the 12 subjects, 8 of them made at least one error managing the eight ACLS scenarios in the first session, and 11 of them made at least one error in the last session. [...] The decrease in alertness and erosion of performance associated with acute continuous sleep loss has been clearly demonstrated, particularly with respect to professional drivers and pilots.9,10,11 Loss of sleep The Impact of 26 Hours of Continuous This project is Wakefulness on Resident Physician Performance Investigators: partially funded by: in the ICU:. [...] This is a state of the art The Impact of 26 Hours of Continuous This project is Wakefulness on Resident Physician Performance Investigators: partially funded by: in the ICU:.