One of the mandates of the Centre for Addiction and Mental Health, and formerly of the Addiction Research Foundation (ARF), is to provide epidemiological monitoring of indicators related to alcohol, tobacco, and drug use, as well as mental health. [...] This report describes four important aspects of the 2006 cycle of the CM series: first, the sampling design and strategy is described; second, the outcome of the sampling strategy and the sample quality are evaluated; third, the instrument and questionnaire items are documented; and fourth, the data file and its characteristics are described. [...] The CAMH Monitor is based on the experience of previous monitoring studies, including the Adult Drug Use series (1977-1991) and the Ontario Alcohol and Other Drug Opinion Survey series (1992-1995). [...] To increase the precision of estimates within different areas of the Province, the sample is equally allocated among six strata according to area code and the corresponding counties (see Table 2). [...] In order to continually assess the quality of responses and to further improve future CM interviews, respondents were asked, at the end of the interview, to evaluate two aspects of the interview -- length and comprehension.