Hexachloroethane (HCE) : Hexachloroéthane (HCE) : no. CAS : 67-72-1

Decisions based on the nature of the critical effects and margins between conservative effect levels and estimates of exposure take into account confidence in the completeness of the identified databases on both exposure and effects, within a screening context. [...] The sources of HCE in indoor air are unidentified, and no information on the presence of HCE in consumer products has been identified in the literature. [...] In NTP (1989), it was concluded that there was “clear evidence” of carcinogenic activity of HCE in male rats based on the increased incidence of renal neoplasms and the possibly HCE- related marginally increased incidence of pheochromocytomas of the adrenal gland. [...] Although the mode of induction of tumours by HCE has not been well studied, the weight of evidence in a relatively robust data set on genotoxicity is negative, suggesting that the mechanism of carcinogenicity is likely to be non-genotoxic and that a level of exposure for which there is no probability of carcinogenic effects is a possibility. [...] Other uncertainties relevant to interpretation of the adequacy of the margin include the limitations of the database on the potential modes of induction of the observed neoplastic effects, which is inadequate to preclude that they result from direct interaction with genetic material.