TITLE: Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines DATE: 15 January 2016 CONTEXT AND POLICY ISSUES Onychomycosis involves fungal infection of the nail bed, matrix or plate and represents about 50% of all nail disorders.1 It occurs mostly in the toenails and less frequently in the fingernails, and can lead to deformity and de [...] The accumulation of 14α-methyl sterols and subsequent loss of ergosterol in the fungal cell wall may be responsible for the antifungal activity of efinaconazole.12 The purpose of this report is to review the clinical efficacy and safety, and cost-effectiveness of efinaconazole for the treatment of fungal nail infections and to review the evidence-based guidelines regarding the treatment of fungal [...] The study was sponsored by the manufacturer and most of the investigators were associated with the manufacturer, hence the potential for bias cannot be ruled out. [...] Summary of Findings What is the clinical effectiveness and safety of efinaconazole for the treatment of fungal nail infections? [...] The mean age of patients in the efinaconazole group was 43 years in one RCT,21 and 52 years (Study 1) and 51 years (Study 2) in the other two RCTs.20 The proportion of females in the efinaconazole group was 54% in one RCT,21 and 26% (Study 1) and 20% (Study 2) in the other two RCTs.20.
- Pages
- 30
- Published in
- Ottawa, Ontario
