The non-randomized studies are made up of five prospective13,16,21-23 and two retrospective cohort investigations.15,24 Details of each study are found in Appendix 2. Clinical effectiveness of the streptococcal antigen test for the detection of pneumonia in pediatric and adult patients The HTA was produced in 2012 by the University of McGill - University Health Centre.8 This assessment included 27 [...] Reviewers obtained literature from the Cochrane Collaboration, the Centre for reviews and Dissemination of the University of York, the International Network of Agencies for Health Technology Assessment, the Canadian Agency for Drugs and Technology in Health, and EMBASE. [...] Their goal was to determine if a UAT reactivity score based on the time for the test to become positive and the intensity of the reactive band might be directly associated with the severity of the disease. [...] Outcomes Sensitivity and specificity of the UAT were the primary outcomes of interest in six of the ten publications assessing clinical effectiveness.1,5,8,13,16,21 The health technology assessment8 also sought to provide an estimation of the costs associated with UAT and the cost of antibiotic treatment used in response to positive or negative results. [...] Cost-effectiveness of the streptococcal antigen test for the detection of pneumonia in pediatric and adult patients Study Designs In addition to the clinical findings, the included HTA8 provided an analysis of cost-effectiveness of UAT.