cover image: Antibiotic impregnated cement for primary hip or knee arthroplasty

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Antibiotic impregnated cement for primary hip or knee arthroplasty

25 Sep 2015

Increasing age, cement costs, and surgery costs were shown to negatively influence the cost- effectiveness of AIC.26 Besides the disagreement in the literature regarding the efficacy of AIC, there is considerable concern about potential risks associated with the use of this technology. [...] Risks such as antibiotic resistance, allergic reactions, kidney damage, systemic toxicity, and mechanical weakening of the cement have been put forth.7,27,28 Given the uncertainty surrounding efficacy and safety of AIC in primary prophylaxis, and the consequent lack of clarity with regards to resource implications, this report will review the clinical and cost-effectiveness of AIC in primary hip a [...] Country of Origin The SRs were conducted by research groups in China,10,48,49 and Australia.5 The non- randomized studies were conducted in Canada,41 and the US.44,46 The economic evaluations were conducted from US,45 and Australian47 perspectives. [...] The length of follow-up for the non-randomized studies ranged from 1 year41 up to a mean range of 53.7 to 55.7 months.46 The time horizon for economic evaluations was the seven year duration of the before-and-after study (2000 until 2007) in one case.45 The second model was evaluated over a time period of 30 years.47 Antibiotic Impregnated Cement for Primary Hip or Knee Arthroplasty. [...] The resource implications of using AIC was assessed by one cost-effectiveness analysis45 and one cost-utility analysis.47 Overall, cost per infection prevented with the introduction of AIC in TKA was high,45 and the combination of antibiotic prophylaxis + AIC dominated, conferring the greatest improvement in utility per cost compared to other infection prevention strategies in THA.47 The cost-effe
health research systematic reviews evaluation obesity antibiotics medical research medicine communicable disease comorbidity clinical trial bias confounding rcts healthcare policy health treatment clinical government health care akaike information criterion diseases and conditions confidence interval adverse effect ci cohort study prophylaxis total knee replacement total hip replacement bone cements aic confounders surgical knee arthroplasty
Pages
41
Published in
Ottawa, Ontario

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