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Tamper-resistant oxycodone

25 Jun 2015

Tamper resistance can take the form of physical barriers (which prevent the drug from being crushed, cut, or dissolved), the addition of aversive agents (which are released when the drug is tampered with and result in an unpleasant drug experience for the user), and the addition of antagonistic agents (these are released if the drug is tampered with and reduce the „high‟ associated with the drug w [...] Critical Appraisal of Individual Studies The included randomized and non-randomized studies were critically appraised using the Downs and Black checklist,10 and economic studies were assessed using the Drummond checklist.11 Critical appraisal of qualitative studies was conducted by assessing whether there was ethics approval, the suitability of the topic to qualitative methods, the adequacy of sam [...] The other cost study,20 that did not include prescription costs, made the assumptions that the rate of prescription pain reliever abuse and dependence was 0.7%, that the ratio of diagnosed to undiagnosed abusers was 1:5, that continuous and non-continuous users of ER oxycodone would be affected by the reformulation in the same way, and that the costs of the Medicare-eligible population reflected t [...] Summary of Critical Appraisal A detailed summary of critical appraisal of individual studies is provided in Appendix 3. Clinical Studies – Randomized Trials Overall, the included RCTs were well-reported with respect to the objectives, interventions, patient characteristics, and outcomes and compliance was reliable in all of the trials.9,12-15 Double-blinding was reported in all of the trials and i [...] The primary limitations of all of the randomized trials related to the included population and conditions for the use of the interventions.9,12-15.
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Pages
38
Published in
Ottawa, Ontario

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