The published research considered in this report is the product of one of the busiest, most fruitful periods of scientif- ic investigation in the history of the Canadian North, the seven-year period starting with International Polar Year in 2007. [...] This interconnectedness makes it difficult to discuss human health and well-being, for example, without touching on the issues of overcrowded housing, the cost of living, building technologies and the warming of permafrost. [...] The interview, literature review and validation phases of this study have confirmed to us the crucial value of traditional knowledge to northern research, especially in the environmental and social domains. [...] Designed and guided by Northerners, its study of the health of streams in the Mackenzie River basin between Tulita and predominance of the minerals and fossil fuels in the region. [...] The cost of living, cost of public services and construction costs are among the highest in the world.