Our objectives were to: (i) assess the effect of antiviral treatment (as a single strategy) and the impact of delays in start of treatment; and (ii) evaluate the combined effect of treatment and post-exposure prophylaxis on antiviral effectiveness. [...] For antiviral strategies, we considered three scenarios for the treatment of index cases, corresponding to an average delay of 1, 2, or 3 days for the initiation of treatment after the onset of symptoms. [...] School-aged children have considerably higher attack rates in all scenarios regardless of the delay in the start of treatment following the onset of symptoms (green curves), and regardless of the treatment coverage. [...] Optimal Treatment Strategies for Remote and Isolated Communities 7 For comparison purposes, we shifted (modified) the demographic variables of the remote community (RC) to resemble those of the Winnipeg health region, the largest urban centre in the province of Manitoba, which has a significant urban Aboriginal population. [...] For an antiviral strategy with a 1-day delay in the start of treatment after the onset of symptoms, the largest drug use occurs in the middle range of treatment and prophylaxis (Figure 5a).