The use of osseo-integrated oral implants has increased recently to replace missing teeth. Dental implants can be used alone or in combination with natural teeth to support fixed or removable dental prostheses. They are of particular interest in the replacement of missing teeth in the distal part of the alveolar arches because the conventional prosthetics produce a cantilever effect on the remaining teeth and compromise their integrity. Another common use of these implants is to support the mandibular complete denture because conventional complete dentures cannot be stabilized easily and is a cause of frustration with patients. To facilitate the decision of introducing dental implant systems in health care facilities, a comprehensive evaluation of the advantages and limits of each system is essential. This report will examine the evidence regarding the comparative clinical effectiveness and safety, in concept, of dental implant therapy and conventional prosthetic therapies.