Over the past decade, pharmacies have increasingly sourced their supply of prescription drugs via third parties, either wholesale or retail distribution networks, rather than receiving them directly from the manufacturer. In light of this trend, the purpose of this study is to report on the wholesale up-charge policies across the NPDUIS participating jurisdictions to better understand the instruments available in controlling related costs. Summaries are provided for British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, New Brunswick, Nova Scotia, Prince Edward Island, Newfoundland and Labrador, the Yukon and the national Non-Insured Health Benefits (NIHB) program.