The report contains a comprehensive review of the existing public literature, studies, materials, and other information and documentation (collectively the ―source documentation) available to CADTH at the time of report preparation, and was guided by expert input and advice throughout its preparation. [...] The antiseptic application techniques also influence the effectiveness of preoperative skin preparation.7 The considerations include size of area of application, mechanism of application (for example, application in concentric circles), type of instrument used, and timing and duration of application of solution.3 CDC guidelines recommend that patients shower or bathe with an antiseptic the night b [...] All studies reported the selection of patients in different intervention groups from a common population over the same period,12,13,15,16 except the time period cohort study.14 Both RCTs reported the randomization of patients into intervention groups,12,13 and one used an appropriate method of randomization and concealed allocation.13 Three studies did not adjust for confounding,12,13,15 and five [...] Patient characteristics One study involved clean elective hernia repair18 and the other involved clean plastic surgery.19 The mean age of patients was 33 years.19,20 Of the hernia patients, 91% were male,18 and 64% of plastic surgery patients were female.19 Interventions and comparators One RCT studied PI scrub and paint compared with soap scrub and paint with methylated spirit,18 and the other co [...] Comparison of Antiseptics Study characteristics The clinical effectiveness of one antiseptic preparation compared with another for reducing bacterial colonization and SSIs was reported in five RCTs, two cohort studies, and one case- control study published between 2002 and 2011.20-27 The studies were conducted in hospitals in Thailand,21 Kuwait,22 Brazil,23 Israel,25 and the United States.20,24,26
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- Published in
- Canada
