Morphogenetic bone for fracture healing

Health technology assessments In 2007, Garrison et al.1 produced a HTA report with the objective of assessing the clinical- effectiveness and cost-effectiveness of BMPs in the non-healing of fractures and spinal fusion, relative to the current standards of care. [...] The authors of the report expressed concern there were differences in the baseline characteristics of patients in the treatment and control groups in a number of the included RCTs and that these characteristics could potentially affect healing and bias the results. [...] Further, the included RCTs were of low to moderate quality according to the quality assessment performed by the authors of the HTA report and the length of follow-up in some studies may have been insufficient to assess some outcomes. [...] In 2005, the ECRI Institute published an HTA report that evaluated rhBMP-7 for healing nonunion of tibial fractures.4 The purpose of the report was to determine if the OP-1 implant (rhBMP-7) resulted in better health-systems-related, radiographic, and patient-oriented outcomes than those of bone autografting in the treatment of nonunion of tibial fractures, and how the complication rates of the tw [...] In 2005, Ontario’s Medical Advisory Secretariat published an evidence-based review of the clinical efficacy of the OP-1 implant for long bone nonunion.5 Specific objectives were to summarize the safety and efficacy profiles of the OP-1 implant in the treatment nonunion and bone defects and to compare its clinical- and cost-effectiveness with the alternative technologies, in particular, autogenous