The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. [...] Non-randomized studies Studies in a surgical setting A group of researchers published two prospective observational studies that evaluated the performance of latex and non-latex gloves during orthopedic surgery (Appendix 1).1,2 The primary knee and hip arthroplasties were performed by the same surgeons at two hospitals in the UK. [...] The 2011 study2 failed to report the methods used to evaluate the general usability of the gloves, and neither study stated the composition of the non-latex gloves. [...] The study was funded by Regent Medical Overseas and Mölnlycke Health care, the manufacturer of two of the gloves tested.4 Boccellino et al.6 evaluated the permeability of latex and nitrile gloves to doxorubicin in saline and acidic solutions. [...] The authors concluded that the permeability of gloves to doxorubicin depends on the pH and the glove material.6 Wallemacq et al.