Addendum to a systematic review of clinical, laboratory and safety outcomes associated with use of Octaplas in multiple clinical indications

Given the poor quality and Because of the limited data comparing the quantity of evidence for the effectiveness effectiveness and safety of Octaplas and of both Octaplas and comparators, FFP, the health services impact cannot be Octaplas may be a reasonable alternative determined. [...] Clinical Review of Efficacy and Effectiveness Methods A systematic electronic literature search update of MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials was conducted to identify all recent relevant randomized and observational studies pertaining to evaluation of the effectiveness and safety of Octaplas. [...] However, no formal cost analysis was performed.1 Addendum to a Systematic Review of Clinical, Laboratory and Safety Outcomes Associated with Use of Octaplas in Multiple Clinical Indications viii Health Services Impact Because of the limited data comparing the effectiveness and safety of Octaplas and FFP, the health services impact cannot be determined. [...] Given the poor quality and quantity of evidence for both the effectiveness of Octaplas and FFP, Octaplas may be a reasonable alternative to FP or FFP in the treatment of bleeding disorders. [...] While several publications claim the in vitro equivalence of Octaplas and FFP in terms of clotting factor activities, the clinical effectiveness of this blood product in the treatment of various indications is not well understood or researched.