The intracameral European Society of Cataract and Refractive injection of antibiotics has been investigated for Surgeons (ESCRS) assessed the clinical the benefit of delivering an instantaneous, high effectiveness of using intracameral cefuroxime concentration of antibiotic to the anterior with or without perioperative topical chamber of the eye at the end of surgery. [...] This report reviews 16,211 patients showed that the absence of the evidence on the clinical effectiveness, safety, prophylactic intracameral cefuroxime was and cost-effectiveness of using intracameral associated with a statistically significant increase antibiotics for the prevention of endophthalmitis in the risk of presumed infectious post-operative after cataract surgery. [...] The results of six observational Research Questions studies support the superiority of using 1. What is the clinical effectiveness of intracameral cefuroxime over alternatives, intracameral antibiotics for the prevention of including topical antibiotics and subconjunctival endophthalmitis post-cataract surgery? [...] Despite these findings, Intracameral cefazolin most guidelines leave the choice of prophylactic Two observational studies showed a statistically antibiotic and mode of administration to the significant reduction in the rate of post-operative individual surgeon’s discretion, and many endophthalmitis with the use of intracameral surgeons favor the use of topical moxifloxacin cefazolin plus topical a [...] The search strategy comprised of antibiotic to the anterior chamber of the eye at controlled vocabulary, such as the National the end of surgery.15 However, the exposure of Library of Medicine’s MeSH (Medical Subject intraocular tissues to high antibiotic Headings) and keywords.