Sepsis management in pediatric patients

Research question: What are the guidelines or protocols for the detection, treatment and management of sepsis in pediatric patients? [...] The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. [...] Details of the identified clinical practice guidelines are presented in Table 1. In the Canadian Paediatric Society guideline, evidence of management of infants at increased risk for sepsis was retrieved through a systematic literature search and evaluated.6. [...] In his guideline in 2004, quality of the evidence and grading of recommendations were based on a system proposed by Sackett in 1989;7 while in the 2008 guideline, they were judged by pre-defined Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach.3 In the GRADE system, quality of evidence was classified as high (Grade A), moderate (Grade B), low (Grade C) or very low [...] Recommendations between the two guidelines were similar but not identical, partly as a result of the inclusion of more clinical trials in the 2008 guideline.