Between 50% and 70% of palliative cancer patients experience dyspnea in the last six weeks of life and the condition is aggravated with the progression of cancer.1,3,4. [...] The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. [...] In 24 hours non-statistical significant breakthrough dyspnea was observed in 34.3% of patients in the Dyspnea Management in Palliative Cancer Patients. [...] Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians.