The application of uncertainty factors and the Pest Control Products Act factor in the human health risk assessment of pesticides : Utilisation de facteurs d'incertitude et du facteur issu de la Loi sur les produits antiparasitaires dans l'évaluation des risques des pesticides pour la santé humaine

The adequacy of the magnitude of the MOE is assessed in light of the uncertainties and findings of the database. [...] The magnitude of the selected factor will be based upon the level of response at the LOAEL, the nature of the effect and the steepness of the dose-response curve. [...] Hence, the use of a factor for database deficiency primarily reflects the absence of key data in the hazard component of the risk assessment for a given pesticide. [...] The magnitude of the factor will be influenced by the level of concern generated by the database and the potential impact of the missing information. [...] Science Policy Note - SPN2008-01 Page 11 4.2 Completeness of the Data While the new PCPA provisions focus attention on the safety of infants and children, it was the PMRA’s practice, prior to and after enactment of the PCPA, to assess the completeness of the pesticide database for hazard identification and quantification.