cover image: Pulsatile machine perfusion compared to cold storage in kidney preservation = : Comparaison entre la machine à perfusion et le stockage sur glace pour la conservation des reins

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Pulsatile machine perfusion compared to cold storage in kidney preservation = : Comparaison entre la machine à perfusion et le stockage sur glace pour la conservation des reins

16 Aug 2007

Ischemia leads to a shortage of oxygen and nutrients, loss of metabolic activity which initiates a process of cellular damage with the degradation of compounds that are necessary for the cell metabolism, and the activation of degenerative enzymes5. [...] This leads to the loss of structural and functional components of the cell5 which may result in delayed function or even permanent organ dysfunction 6 7. Preservation of the kidney from the time of harvesting through the period of tissue typing, matching and transplantation allows the maintenance of the organ functions after the transplantation and is expected to reduce the risk of post-transplant [...] Another purported advantage of machine perfusion is that it allows for testing the viability of the organ before the transplantation thereby avoiding the transplantation of an organ that would not achieve function7. [...] However, with the idea of expanding the kidney donor pool in order to include NHBD and ECD donors 7 and the development of new preservation solutions there has been a renewed interest in the use of machine perfusion7. [...] It is unlikely that the use of the machine will increase the number of transplantations performed annually at the MUHC (information from Dr.
health health facility cost-benefit analysis medicine cost-effectiveness analysis meta-analysis kidney transplantation clinical medicine ischemia health treatment health sciences medical specialties hospital and clinic chronic kidney disease renal transplantation hemodialysis kidneys esrd kidney transplantations organ preservation perfusion machine perfusion

Authors

Costa, Vania

Pages
44
Published in
Canada

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