Overview of recombinant human growth hormone for treatment of Turner syndrome

The underlying assumed weight for the five- and 12-year-old girls is 18 kg and 42 kg respectively.13 2 Objectives This report assesses the clinical effectiveness and cost-effectiveness of rhGH therapy for TS and addresses the following questions: • Compared with no therapy, what is the clinical effect of rhGH for the treatment of the short stature associated with TS? [...] Bone age and height ranged from 7.2 to 8.9 years and 114 to 122 cm respectively in five RCTs.14-17,20 The karyotype (45,X) of the patients was reported in four RCTs.14,17,19,20 The percentage of patients having the 45,X karyotype varied between 55% and 95%. [...] Using a combination of the Jadad scale and the Hailey scale to judge the reporting quality, two RCTs14,15 were judged to be of high quality, three RCTs16-18 of good quality, and one RCT19 of fair quality. [...] Using a combination of the Jadad scale and the Hailey scale to judge the reporting quality of the comparative observational studies, one study21 was judged to be of good quality, six 21-23,25,28,29 of fair quality, and two26,27 of poor quality. [...] GV and GVSDS were higher for patients treated with rhGH compared with patients not receiving rhGH (Tables 2 and 3), hence favouring the use of rhGH in patients with TS.