The starting point for meeting a decision maker’s needs is to Transparency: A key concept in the Economic frame the study question of an economic Guidelines is the need for transparency in the evaluation in a way that directly addresses the reporting of an evaluation. [...] The Economic Guidelines also allows users to critically appraise the emphasize the use of “real world” data, and the methodological quality of the evaluation, and to simulation of “real world” scenarios. [...] Beyond the usefulness existing programs.10 Problems of relevance include of the actual results of an analysis, economic the use of inappropriate comparators, the lack of evaluations synthesize evidence and assumptions in “real world” data in the analysis, the lack of a way that provides users of the information with a appropriate subgroup analysis, and poor structured way of thinking and useful in [...] State and justify 2.14 Generalizability any assumptions regarding the range of values for key parameters, the form of 2.14.1 Address generalizability in the design of probability distributions, and the number the evaluation and in the interpretation of of Monte Carlo iterations. [...] There are five types of economic evaluations (i.e., CUA, CEA, CMA, CBA, and CCA).17 The Analysts are encouraged to select an outcome selection of the appropriate type of evaluation indicator that is most appropriate for the relevant depends on the research question, the condition of condition, and most feasible, given the available interest, and the availability of data on outcomes.