Authorship Srabani Banerjee coordinated the project and was involved in the protocol development; article selection; data extraction and analysis; and preparation of the report. [...] Shaila Mensinkai was involved in developing the protocol, in conducting the literature search and in writing the literature search method and associated appendix for the report. [...] Acknowledgements The authors thank Catherine Allison for her input and for writing the Report in Brief, Lynn Brodsky and Chuong Ho for their input and help in checking data, Christine Murray and Isabella Steffensen for their assistance with the data extraction and Clara Pham for her assistance with the data extraction and checking. [...] Based on the • To identify the risks associated with LVRS and compromised quality of life experienced by to evaluate what level of risk is appropriate in patients with severe emphysema, it is difficult to patients with a compromised quality of life. [...] A subtype of chronic obstructive pulmonary disease (COPD), emphysema is characterized by the destruction of alveolar walls and hyperinflation of the lungs, which result in shortness of breath, decreased exercise capacity and reduced quality of life (QoL).