The accuracy of the contents of the source documentation on which this report is based is not warranted, assured or represented in any way by CCOHTA and CCOHTA does not assume responsibility for the quality, propriety, inaccuracies or reasonableness of any statements, information or conclusions contained in the source documentation. [...] Chuong Ho led the protocol development, supervised the literature review, wrote the draft, revised the report and prepared the report for publication. [...] The addition of a stent reduces the risk of abrupt reclosure and restenosis after coronary angioplasty, but it also increases the risk of thrombus formation at the implantation site. [...] When the importance of the GP IIb/IIIa receptor was realized, this led to the development of three intravenous antagonists: abciximab, eptifibatide and tirofiban. [...] In this report, we review the available evidence from RCTs of the clinical benefit and harm associated with the use of GP IIb/IIIa antagonists in patients undergoing PCIs.