This disclaimer and any questions or matters of any nature arising from or relating to the content or use (or misuse) of this document will be governed by and interpreted in accordance with the laws of the Province of Ontario and the laws of Canada applicable therein, and all proceedings shall be subject to the exclusive jurisdiction of the courts of the Province of Ontario, Canada. [...] The purpose of this Rapid Response is to identify the clinical effectiveness of seasonal influenza immunization in health care workers to prevent the spread of influenza to patients. [...] Key Findings One overview of systematic reviews and two non-randomized studies were identified regarding the clinical effectiveness of seasonal influenza immunization of health care workers to prevent the spread of influenza to patients. [...] Two of the non-randomized studies were in favour of the use of influenza vaccine, while the overview of systematic reviews reported conflicting results. [...] More research needs to be conducted in order to support or oppose the use of the influenza vaccination in health care workers to prevent the spread of influenza to patients.