Summary of Study Characteristics A summary of the characteristics of the included literature is presented in Appendix 2. Clinical Benefits and Harms of Basal-Bolus Versus Sliding-Scale Insulin Therapy in the Acute Care Hospital Setting A total of one SR5 and three primary studies1,3,8 provided information on the clinical effectiveness and safety of basal-bolus versus sliding-scale insulin therapy [...] Summary of Critical Appraisal A summary of the critical appraisal of the included literature is presented in Appendix 3. Clinical Benefits and Harms of Basal-Bolus Versus Sliding-Scale Insulin Therapy in the Acute Care Hospital Setting The SR5 was of mixed quality based on the assessment conducted with the AMSTAR tool.6 The SR5 provided a detailed literature search strategy, listed the included st [...] For bias, the statistical tests used to assess the main outcomes were appropriate, and the main outcome measures were valid and reliable in both studies.3,8 For confounding, in both studies,3,8 the study subjects in different intervention groups were recruited from the same population over the same period of time. [...] Summary of Findings A summary of the findings of the included literature is presented in Appendix 4. What is the comparative clinical effectiveness of basal-bolus versus sliding-scale insulin therapy for adult patients with type 1 and type 2 diabetes in the acute care hospital setting? [...] The results of the meta-analysis reported in the SR5 were associated with large heterogeneity, reflecting significant differences in the study design, definitions of adverse events, and follow-up durations across the included studies5 and need to be confirmed.