Despite the paucity of clinical guidance, the combination of multiple APs (combination AP therapy or AP polypharmacy) has emerged as a means of enhancing the therapeutic effects of AP monotherapy in partial- or non-responders, treating co-morbidities, reducing the dose of the baseline AP, or addressing adverse side effects of the baseline AP.3,8,9 Combination AP therapy is reportedly driven by the [...] Two of the included RCTs were from the same authors.23,24 One SR each was published in 2010,20 2012,19 2014,18 and 2015.17 Five of the RCTs were published in 2012,9,24-27 and one each in 2014,23 2015,22 and 2016.21 One guideline was published in 201129 and the other in 2013.28 Each SR included a MA of RCTs with follow-up time periods ranging from six weeks19 to three 20 23,24 years. [...] Country of Origin One SR was published in Italy,19 one in Thailand,17 one in Japan, Austria, and Canada,18 and one in China, Japan, the United Kingdom and Brazil.20 Three of the RCTs enrolled patients in Japan,9,23,24 two in China,21,22 one each in Finland,27 Sweden,26 and one in Brazil and the United States.25 Both guidelines were authored in the United Kingdom.28,29 Patient Population The SRs in [...] A procedure for updating the guideline was not provided, and it was unclear in both guidelines whether the views and preferences of the target population were represented in the guideline development group.28,29 Details on the procedure for updating the guideline, monitoring or auditing criteria, funding source and how conflicts of interest were managed were missing in one guideline.28 In one guid [...] Did not provide a list of excluded studies Provided list of included studies as well as The funding source was not disclosed study characteristics Assessed the quality of the included studies Qualitatively assessed publication bias Reported on the quality of the studies included in the meta-analysis Provided quantitative comparison Authors declared that they had no conflict of inte
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