Daptomycin for methicillin-resistant and methicillin-sensitive staphylococcus aureus infection

Unlike vancomycin which has not proven effective to treat bacteremia caused by MSSA, daptomycin has been found to be similarly efficacious as cloxacillin and vancomycin for the treatment of bacteremia caused by MSSA and MRSA, respectively.8 The aim of this review is to summarize evidence on the comparative clinical and cost effectiveness of daptomycin to other antibiotics for the treatment of bact [...] The strengths and limitations of the individual studies are summarized in Appendix 3. SUMMARY OF EVIDENCE Quantity of Research Available A total of 464 citations were identified in the literature search. [...] Evidence for the recommendations in each of the guidelines was based on literature from systematic searches of relevant databases, combined with opinions of experts in field.8,17,18 Country of Origin One systematic review13 was authored by investigators from The United Kingdom (UK) and the United States of America (USA). [...] The study18 also provided some itemized costs alongside the total costs of therapy to facilitate the assessment of the contributions of the Daptomycin for Methicillin-Resistant and Methicillin-Sensitive Staphylococcus Aureus Infection. [...] However, with data from a single hospital in the USA, and given that the analysis was based on historical costs without discounting for the future, the generalizability of the study findings to the Canadian context is unknown.